P-108: Efficacy of Intrauterine Injection of Granulocyte Colony Stimulating Factor on Treatment of Unexplained Recurrent Miscarriage

Background Effects of GCSF (Granulocyte Colony-stimulating Factor) injection in patients suffering from recurrent pregnancy loss has been studied in some studies and we now know that transvaginal perfusion of G-CSF might be helpful for improvement of implantation rate among patients with thin endometrium and patients under in vitro fertilization /embryo transfer (IVF/ET) or intracytoplasmic sperm injection (ICSI)/ ET. The aim of present study was to evaluate the impact of intrauterine injection of G-CSF in patients that suffering from unexplained recurrent miscarriage.9 MaterialsAndMethods In present randomized clinical trial a total of 67 patients were randomly allocated into two study groups including intrauterine G-CSF (300 �g) injection and control group (no G-CSF injection). All patients were in ovulation induction (OI) cycle. In G-CSF group, intrauterine injection of G-CSF were done twice in cycle. All enrolled patients were under 40 years old and had at least two times unexplained abortion. Pregnancy was evaluated by titer of �hCG in institute�s lab, presence of gestational sac (implantation) was assessed by vaginal sonography and finally clinical pregnancy was confirmed by detection of fetal heart rate (FHR). Results A total of 17 patients were excluded from the final analysis due to different reasons. No significant difference were observed between two study groups when we compared the rate of pregnancy (P=1.000), implantation (P=0.491), clinical pregnancy (P=0.414) and abortion (P=0.414). Conclusion s:450:"In contrast to possible effect of G-CSF on improvement of implantation rate that revealed by some other studies, based on the result of present study we couldn�t suggest intrauterine injection of G-CSF for improvement of clinical pregnancy rate and reduce of abortion among patients with unexplained recurrent miscarriage. Further molecular biology studies are needed to clarify the mechanism in which G-CSF affects the pregnancy process. ,"";